Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.
Identifieur interne : 001F07 ( Main/Exploration ); précédent : 001F06; suivant : 001F08Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.
Auteurs : Jenny Blechinger [Allemagne] ; Hanna Pieper ; Paul Marzenell ; Larisa Kovbasyuk ; Andrius Serva ; Vytaute Starkuviene ; Holger Erfle ; Andriy MokhirSource :
- Chemical communications (Cambridge, England) [ 1364-548X ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- antagonistes et inhibiteurs : microARN.
- pharmacologie : Oligonucléotides, Stilbènes.
- Cellules HeLa, Humains, Oligonucléotides, Régulation négative, Stilbènes, Séquence nucléotidique, microARN.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : MicroRNAs.
- chemical , chemistry : MicroRNAs, Oligonucleotides, Stilbenes.
- drug effects : Down-Regulation.
- chemical , pharmacology : Oligonucleotides, Stilbenes.
- Base Sequence, HeLa Cells, Humans.
Abstract
We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.
DOI: 10.1039/c3cc43174f
PubMed: 23863995
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001C53
- to stream PubMed, to step Curation: 001C53
- to stream PubMed, to step Checkpoint: 001A64
- to stream Ncbi, to step Merge: 000A85
- to stream Ncbi, to step Curation: 000A85
- to stream Ncbi, to step Checkpoint: 000A85
- to stream Main, to step Merge: 001F23
- to stream Main, to step Curation: 001F07
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.</title><author><name sortKey="Blechinger, Jenny" sort="Blechinger, Jenny" uniqKey="Blechinger J" first="Jenny" last="Blechinger">Jenny Blechinger</name><affiliation wicri:level="1"><nlm:affiliation>Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 42, 91054 Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 42, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Pieper, Hanna" sort="Pieper, Hanna" uniqKey="Pieper H" first="Hanna" last="Pieper">Hanna Pieper</name></author><author><name sortKey="Marzenell, Paul" sort="Marzenell, Paul" uniqKey="Marzenell P" first="Paul" last="Marzenell">Paul Marzenell</name></author><author><name sortKey="Kovbasyuk, Larisa" sort="Kovbasyuk, Larisa" uniqKey="Kovbasyuk L" first="Larisa" last="Kovbasyuk">Larisa Kovbasyuk</name></author><author><name sortKey="Serva, Andrius" sort="Serva, Andrius" uniqKey="Serva A" first="Andrius" last="Serva">Andrius Serva</name></author><author><name sortKey="Starkuviene, Vytaute" sort="Starkuviene, Vytaute" uniqKey="Starkuviene V" first="Vytaute" last="Starkuviene">Vytaute Starkuviene</name></author><author><name sortKey="Erfle, Holger" sort="Erfle, Holger" uniqKey="Erfle H" first="Holger" last="Erfle">Holger Erfle</name></author><author><name sortKey="Mokhir, Andriy" sort="Mokhir, Andriy" uniqKey="Mokhir A" first="Andriy" last="Mokhir">Andriy Mokhir</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23863995</idno><idno type="pmid">23863995</idno><idno type="doi">10.1039/c3cc43174f</idno><idno type="wicri:Area/PubMed/Corpus">001C53</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C53</idno><idno type="wicri:Area/PubMed/Curation">001C53</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C53</idno><idno type="wicri:Area/PubMed/Checkpoint">001A64</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001A64</idno><idno type="wicri:Area/Ncbi/Merge">000A85</idno><idno type="wicri:Area/Ncbi/Curation">000A85</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A85</idno><idno type="wicri:Area/Main/Merge">001F23</idno><idno type="wicri:Area/Main/Curation">001F07</idno><idno type="wicri:Area/Main/Exploration">001F07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.</title><author><name sortKey="Blechinger, Jenny" sort="Blechinger, Jenny" uniqKey="Blechinger J" first="Jenny" last="Blechinger">Jenny Blechinger</name><affiliation wicri:level="1"><nlm:affiliation>Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 42, 91054 Erlangen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 42, 91054 Erlangen</wicri:regionArea><wicri:noRegion>91054 Erlangen</wicri:noRegion><placeName><settlement type="city">Erlangen</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Moyenne-Franconie</region></placeName></affiliation></author><author><name sortKey="Pieper, Hanna" sort="Pieper, Hanna" uniqKey="Pieper H" first="Hanna" last="Pieper">Hanna Pieper</name></author><author><name sortKey="Marzenell, Paul" sort="Marzenell, Paul" uniqKey="Marzenell P" first="Paul" last="Marzenell">Paul Marzenell</name></author><author><name sortKey="Kovbasyuk, Larisa" sort="Kovbasyuk, Larisa" uniqKey="Kovbasyuk L" first="Larisa" last="Kovbasyuk">Larisa Kovbasyuk</name></author><author><name sortKey="Serva, Andrius" sort="Serva, Andrius" uniqKey="Serva A" first="Andrius" last="Serva">Andrius Serva</name></author><author><name sortKey="Starkuviene, Vytaute" sort="Starkuviene, Vytaute" uniqKey="Starkuviene V" first="Vytaute" last="Starkuviene">Vytaute Starkuviene</name></author><author><name sortKey="Erfle, Holger" sort="Erfle, Holger" uniqKey="Erfle H" first="Holger" last="Erfle">Holger Erfle</name></author><author><name sortKey="Mokhir, Andriy" sort="Mokhir, Andriy" uniqKey="Mokhir A" first="Andriy" last="Mokhir">Andriy Mokhir</name></author></analytic><series><title level="j">Chemical communications (Cambridge, England)</title><idno type="eISSN">1364-548X</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term><term>Down-Regulation (drug effects)</term><term>HeLa Cells</term><term>Humans</term><term>MicroRNAs (antagonists & inhibitors)</term><term>MicroRNAs (chemistry)</term><term>Oligonucleotides (chemistry)</term><term>Oligonucleotides (pharmacology)</term><term>Stilbenes (chemistry)</term><term>Stilbenes (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules HeLa</term><term>Humains</term><term>Oligonucléotides ()</term><term>Oligonucléotides (pharmacologie)</term><term>Régulation négative ()</term><term>Stilbènes ()</term><term>Stilbènes (pharmacologie)</term><term>Séquence nucléotidique</term><term>microARN ()</term><term>microARN (antagonistes et inhibiteurs)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>MicroRNAs</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>MicroRNAs</term><term>Oligonucleotides</term><term>Stilbenes</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>microARN</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Down-Regulation</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oligonucléotides</term><term>Stilbènes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oligonucleotides</term><term>Stilbenes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term><term>HeLa Cells</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HeLa</term><term>Humains</term><term>Oligonucléotides</term><term>Régulation négative</term><term>Stilbènes</term><term>Séquence nucléotidique</term><term>microARN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Moyenne-Franconie</li></region><settlement><li>Erlangen</li></settlement></list><tree><noCountry><name sortKey="Erfle, Holger" sort="Erfle, Holger" uniqKey="Erfle H" first="Holger" last="Erfle">Holger Erfle</name><name sortKey="Kovbasyuk, Larisa" sort="Kovbasyuk, Larisa" uniqKey="Kovbasyuk L" first="Larisa" last="Kovbasyuk">Larisa Kovbasyuk</name><name sortKey="Marzenell, Paul" sort="Marzenell, Paul" uniqKey="Marzenell P" first="Paul" last="Marzenell">Paul Marzenell</name><name sortKey="Mokhir, Andriy" sort="Mokhir, Andriy" uniqKey="Mokhir A" first="Andriy" last="Mokhir">Andriy Mokhir</name><name sortKey="Pieper, Hanna" sort="Pieper, Hanna" uniqKey="Pieper H" first="Hanna" last="Pieper">Hanna Pieper</name><name sortKey="Serva, Andrius" sort="Serva, Andrius" uniqKey="Serva A" first="Andrius" last="Serva">Andrius Serva</name><name sortKey="Starkuviene, Vytaute" sort="Starkuviene, Vytaute" uniqKey="Starkuviene V" first="Vytaute" last="Starkuviene">Vytaute Starkuviene</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Blechinger, Jenny" sort="Blechinger, Jenny" uniqKey="Blechinger J" first="Jenny" last="Blechinger">Jenny Blechinger</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F07 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F07 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:23863995
|texte= Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23863995" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |